Description

3,5-Bis(Trifluoromethyl)Benzylamine is a high-value, multi-functional aromatic amine building block characterized by its electron-deficient bis(trifluoromethyl)benzene core. This compound matters for its unique combination of a reactive primary amine group with the exceptional lipophilicity, metabolic stability, and strong electron-withdrawing properties imparted by the trifluoromethyl groups. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing kinase inhibitors, receptor antagonists, and other small-molecule drugs where the CF3 groups enhance bioavailability and binding affinity.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides, where the trifluoromethyl groups contribute to improved pest selectivity, rainfastness, and overall efficacy.
• Ligand & Catalyst Development: Serves as a precursor for chiral and achiral ligands in asymmetric catalysis and transition metal complexes used in cross-coupling and other specialty reactions.
• Advanced Material Monomer: Employed in the research and production of high-performance polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties and solubility.
• Fluorinated Compound Library: A key reagent for medicinal chemistry and combinatorial chemistry in constructing diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Benzylamine
CAS No.	85068-29-7
Molecular Formula	C9H7F6N
Molecular Weight	243.15 g/mol
Synonyms	[3,5-Bis(trifluoromethyl)phenyl]methanamine; α,α,α,α',α',α'-Hexafluoro-3,5-xylylamine; 1-[3,5-Bis(trifluoromethyl)phenyl]methanamine; 3,5-Bis(trifluoromethyl)benzenemethanamine; (3,5-Bis(trifluoromethyl)phenyl)methylamine; 3,5-Bis(trifluoromethyl)benzyl amine; 85068-29-7; 3,5-Di(trifluoromethyl)benzylamine
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Benzylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This amine is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation. Keep away from strong oxidizing agents and acids.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.