Description

4'-(Trifluoromethoxy)Acetophenone is a versatile fluorinated aromatic ketone building block, identified by CAS NO 85013-98-5. This compound is valued for its trifluoromethoxy (-OCF₃) substituent, which imparts unique electronic and lipophilic properties critical for advanced material and pharmaceutical synthesis. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for introducing the metabolically stable trifluoromethoxy pharmacophore.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the -OCF₃ group improves product efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Functional Material Development: Employed in creating specialty polymers, coatings, and additives that benefit from the introduced fluorine's properties.
• Chemical Research & Development: A valuable building block in academic and industrial labs for exploring new reactions and creating novel fluorinated compound libraries.

Basic Information

Product Name	4'-(Trifluoromethoxy)Acetophenone
CAS No.	85013-98-5
Molecular Formula	C₉H₇F₃O₂
Molecular Weight	204.15 g/mol
Synonyms	1-[4-(Trifluoromethoxy)phenyl]ethanone; 4-Acetylphenyl trifluoromethyl ether; p-(Trifluoromethoxy)acetophenone; 4-Trifluoromethoxyacetophenone; 4'-Trifluoromethoxyacetophenone; TFMO-Acetophenone; 85013-98-5; Ethanone, 1-[4-(trifluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 4'-(Trifluoromethoxy)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.