Description

3-Aminophenylboronic Acid Hydrochloride is a versatile organoboron compound that serves as a critical building block in modern synthetic chemistry. Its dual functionality, featuring both a boronic acid group and a primary amine, makes it an essential reagent for Suzuki-Miyaura cross-coupling reactions and other catalytic processes. This high-purity intermediate is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers for the synthesis of active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of complex drug molecules, particularly in oncology and CNS therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Essential reagent for forming carbon-carbon bonds between aryl halides and boronic acids, a cornerstone of modern medicinal chemistry.
• Protease Inhibitor Synthesis: Used in the development of boronic acid-based protease inhibitors for treating various diseases.
• Material Science & OLED Development: Precursor for creating organic electronic materials, including emissive layers in OLED displays.
• Bioconjugation & Sensor Development: Facilitates the labeling and modification of biomolecules for diagnostic assays and biosensors.
• Polymer Chemistry: Monomer for synthesizing specialty polymers with unique thermal or electronic properties.
• Academic & Industrial Research: Fundamental reagent in chemical libraries for high-throughput screening and discovery chemistry.

Basic Information

Product Name	3-Aminophenylboronic Acid Hydrochloride
CAS No.	85006-23-1
Molecular Formula	C6H9BClNO2
Molecular Weight	173.41 g/mol
Synonyms	(3-Aminophenyl)boronic acid hydrochloride; 3-Aminobenzeneboronic acid HCl; m-Aminophenylboronic acid hydrochloride; B-(3-Aminophenyl)boronic acid hydrochloride; 3-Carbamoylphenylboronic acid hydrochloride (common misnomer); APBA-HCl; 3-NH2-PhB(OH)2·HCl
EINECS	Contact for details

Quality Control

Our 3-Aminophenylboronic Acid Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Production adheres to cGMP guidelines where applicable, and each lot is supported by a comprehensive Certificate of Analysis (COA). The QC protocol includes identity confirmation by spectroscopic methods, precise quantification of assay and impurity profiles via HPLC, and stringent control of residual solvents and heavy metals to meet the exacting standards of pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.