Description

2-Chlorobutyl Chloroformate is a versatile and highly reactive chloroformate ester, serving as a critical reagent for introducing the 2-chlorobutoxycarbonyl protecting group. This compound matters for its role in facilitating complex synthetic transformations, particularly in the controlled synthesis of pharmaceuticals and fine chemicals where selective protection and activation are required. It is primarily needed by research chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for applications in peptide synthesis and as a key intermediate in multi-step organic syntheses.

Application

• As a key reagent for the introduction of the 2-chlorobutoxycarbonyl (2-Cl-Boc) protecting group in peptide and organic synthesis.
• Intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs) and complex drug molecules.
• Used in the preparation of agrochemical intermediates requiring specific chloroformate functionalities.
• Reagent for the synthesis of carbonates and urethanes in polymer and materials science research.
• Employed in laboratory-scale process development and optimization for scale-up to pilot and commercial production.
• Building block for the creation of specialized chemical libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	2-Chlorobutyl Chloroformate
CAS No.	84697-15-4
Molecular Formula	C5H8Cl2O2
Molecular Weight	171.02 g/mol
Synonyms	2-Chlorobutyl carbonochloridate; Chloroformic Acid 2-Chlorobutyl Ester; 2-Chlorobutyl Chlorocarbonate; 1-Chloro-2-butyl Chloroformate; Butyl-2-chloro Chloroformate; Carbonochloridic Acid, 2-Chlorobutyl Ester; NSC 163045
EINECS	Contact for details

Quality Control

Our 2-Chlorobutyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 15-25°C. Due to its hygroscopic and moisture-sensitive nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, strong oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.22 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.