Description

cis-2-Aminocyclobutane-1-Carboxylic Acid is a conformationally constrained, non-proteinogenic amino acid featuring a cyclobutane ring. This unique structure makes it a valuable building block in medicinal chemistry for designing novel peptide mimetics and bioactive compounds. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis sectors for applications in drug discovery and development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Design: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core scaffold in the design of inhibitors for various enzymatic targets.
• Chemical Biology Probes: Incorporated into molecular probes to study protein-protein interactions and enzyme mechanisms.
• Ligand Synthesis for Catalysis: Employed in the preparation of chiral ligands for asymmetric synthesis.
• Academic & Industrial Research: A versatile tool for exploratory research in organic synthesis and medicinal chemistry.

Basic Information

Product Name	cis-2-Aminocyclobutane-1-Carboxylic Acid
CAS No.	84585-76-2
Molecular Formula	C5H9NO2
Molecular Weight	115.13 g/mol
Synonyms	(1R,2S)-2-Aminocyclobutane-1-carboxylic acid; (1S,2R)-2-Aminocyclobutane-1-carboxylic acid; cis-2-Aminocyclobutanecarboxylic acid; cis-ACBC; 2-Amino-cis-cyclobutanecarboxylic acid; (1R,2S)-rel-2-Aminocyclobutanecarboxylic Acid; Cyclobutane amino acid
EINECS	Contact for details

Quality Control

Our cis-2-Aminocyclobutane-1-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity and impurity profile analysis, to ensure it meets the high standards required for research and synthesis. A Certificate of Analysis (COA) detailing purity, identity, and specific test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.