Description

2-[1-(4-Chlorophenyl)Cyclobutyl]Acetic Acid is a specialized organic acid building block featuring a cyclobutyl core substituted with a chlorophenyl group. This compound matters as a critical intermediate in the synthesis of complex pharmaceutical molecules and advanced materials, offering a unique structural motif for drug discovery and chemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, leveraging the chlorophenyl moiety.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where the rigid cyclobutyl structure imparts specific physical properties.
• Chemical Biology Probes: Utilized in the development of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific scaffold.

Basic Information

Product Name	2-[1-(4-Chlorophenyl)Cyclobutyl]Acetic Acid
CAS No.	84485-51-8
Molecular Formula	C12H13ClO2
Molecular Weight	224.68 g/mol
Synonyms	2-[1-(4-Chlorophenyl)cyclobutyl]acetic acid; 2-(1-(4-Chlorophenyl)cyclobutyl)acetic acid; 4-Chloro-α-(1-cyclobutyl)benzeneacetic acid; 2-(p-Chloro-α-cyclobutylbenzyl)acetic acid; (4-Chlorophenyl)cyclobutylacetic acid; 84485-51-8; CCRIS 9388; NSC 406079
EINECS	Contact for details

Quality Control

Our 2-[1-(4-Chlorophenyl)Cyclobutyl]Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, oxidizing agents, and heat sources. Due to its acidic nature, ensure containers are made of compatible materials and are properly sealed.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.