Description

4-(Difluoromethoxy)Acetophenone is a high-purity fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where the difluoromethoxy group is a critical pharmacophore influencing bioavailability and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy moiety enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs) due to its ability to modify dielectric anisotropy and viscosity.
• Organic Electronics: Employed in the development of novel organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Advanced Polymer Chemistry: Acts as a monomer or cross-linking agent for creating specialty polymers with unique thermal and chemical resistance properties.
• Chemical Research & Development: A versatile reagent for method development and exploring new fluorination chemistry in academic and industrial laboratories.

Basic Information

Product Name	4-(Difluoromethoxy)Acetophenone
CAS No.	83882-67-1
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	1-[4-(Difluoromethoxy)phenyl]ethanone; 4'-Difluoromethoxyacetophenone; p-(Difluoromethoxy)acetophenone; 4-Acetyldifluoromethoxybenzene; Ethanone, 1-[4-(difluoromethoxy)phenyl]-; DFMAP; Difluoromethoxy Phenyl Methyl Ketone
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) with full traceability are provided for every shipment. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.