Description

2-(Chloromethyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a versatile organoboron building block, specifically a pinacol-protected chloromethylboronic ester. This compound is valued for its dual functionality, offering both a reactive chloromethyl group and a protected boronic acid moiety, which is crucial for advanced synthetic transformations. It is primarily sought after by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures, particularly through cross-coupling reactions and polymer modifications.

Application

• Pharmaceutical Intermediate: A key synthon in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that require specific boron-containing scaffolds.
• Polymer & Materials Science: Serves as a functional monomer or cross-linking agent for creating specialty polymers, resins, and advanced materials with tailored properties.
• Ligand & Catalyst Development: Employed in the preparation of novel boron-based ligands and catalysts for asymmetric synthesis and other catalytic processes.
• Organic Electronics: A precursor in the synthesis of organic semiconductors and light-emitting materials for OLEDs and other electronic devices.
• Chemical Biology Probes: Utilized to synthesize bioconjugates and probes for studying biological processes and drug-target interactions.

Basic Information

Product Name	2-(Chloromethyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	83622-42-8
Molecular Formula	C7H14BClO2
Molecular Weight	176.45 g/mol
Synonyms	Chloromethyl Pinacol Boronate; (Chloromethyl)boronic Acid Pinacol Ester; Pinacol (Chloromethyl)boronate; 1-Chloro-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methane; 2-(Chloromethyl)-1,3,2-dioxaborinane, 4,4,5,5-tetramethyl-; B-(Chloromethyl)boronic Acid Pinacol Ester; ChloromethylBpin
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.