Description

1,3,2-Dioxaborolane, 2-(Dichloromethyl)-4,4,5,5-Tetramethyl- is a specialized organoboron reagent featuring a reactive dichloromethyl substituent on the boronate ring. This compound matters as a versatile synthetic intermediate, enabling the introduction of functionalized carbon units in complex molecule construction. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced organic synthesis and medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing chloromethyl or derived functional groups.
• Suzuki-Miyaura Cross-Coupling: Acts as a protected boronic acid equivalent for forming carbon-carbon bonds with aryl/vinyl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific chlorinated motifs.
• Material Science Research: Employed in the development of organic electronic materials, polymers, and ligands where the boronate ester functionality is crucial.
• Chemical Biology Probes: Utilized for synthesizing tagged molecules or activity-based probes for studying biological processes.
• Process Chemistry: Investigated for scalable routes in the production of fine chemicals and complex organic molecules.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-(Dichloromethyl)-4,4,5,5-Tetramethyl-
CAS No.	83622-41-7
Molecular Formula	C7H13BCl2O2
Molecular Weight	211.89 g/mol
Synonyms	2-(Dichloromethyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (Dichloromethyl)boronic acid pinacol ester; Pinacol (dichloromethyl)boronate; Dichloromethylboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(dichloromethyl)-1,3,2-dioxaborolane; B-(Dichloromethyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1,3,2-Dioxaborolane, 2-(Dichloromethyl)-4,4,5,5-Tetramethyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.