Description

4-(Bromomethyl)-2-Chlorobenzonitrile is a versatile halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both bromomethyl and chloro substituents on a benzonitrile core, makes it a valuable precursor for constructing complex molecules through nucleophilic substitution and cross-coupling reactions. This intermediate is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in homogeneous catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers and functionalized polymers with specific electronic or photophysical properties.
• Custom Chemical Synthesis: A critical starting material for contract research organizations (CROs) and fine chemical companies performing bespoke synthesis for clients.
• Life Sciences Reagent: Utilized in biochemical research as a derivatization agent or probe for studying enzyme mechanisms.

Basic Information

Product Name	4-(Bromomethyl)-2-Chlorobenzonitrile
CAS No.	83311-25-5
Molecular Formula	C8H5BrClN
Molecular Weight	230.49 g/mol
Synonyms	2-Chloro-4-(bromomethyl)benzonitrile; 4-Bromomethyl-2-chlorobenzonitrile; 2-Chloro-4-bromomethylbenzonitrile; 1-Bromomethyl-3-chloro-4-cyanobenzene; 3-Chloro-4-cyanobenzyl bromide; (3-Chloro-4-cyanophenyl)methyl bromide; Benzonitrile, 4-(bromomethyl)-2-chloro-; α-Bromo-3-chloro-p-tolunitrile
EINECS	Contact for details

Quality Control

Our production of 4-(Bromomethyl)-2-Chlorobenzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified for high-purity grades.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	85 - 89 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.