Description

Josamycin Propionate is a semi-synthetic macrolide antibiotic derived from josamycin. This compound is valued for its enhanced bioavailability and stability profile compared to its parent molecule, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily utilized by manufacturers in the veterinary and human pharmaceutical sectors for developing potent antibacterial formulations targeting Gram-positive and some Gram-negative pathogens.

Application

• Veterinary Pharmaceutical Intermediate: A key starting material in the production of broad-spectrum antibacterial injectables and oral medications for livestock and companion animals.
• Human Pharmaceutical Synthesis: Serves as a crucial precursor in the research and development of next-generation macrolide antibiotics for clinical use.
• Antibacterial Agent Production: Used in the manufacturing of finished dosage forms effective against respiratory tract, skin, and soft tissue infections.
• Biochemical Research: Employed as a reference standard in microbiological assays and studies of bacterial protein synthesis inhibition.
• API Manufacturing: An important building block for Active Pharmaceutical Ingredient (API) producers requiring high-purity macrolide derivatives.

Basic Information

Product Name	Josamycin Propionate
CAS No.	83310-75-2
Molecular Formula	C45H75NO17
Molecular Weight	878.1 g/mol
Synonyms	Josamycin propanoate; Propionyljosamycin; Josamycin propionate ester; (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-4-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-12,13-dihydroxy-7-{[(2R,3S,4S,6S)-3-(dimethylamino)-4-hydroxy-6-methyloxan-2-yl]oxy}-3,5,7,9,11,13-hexamethyl-6-{[(2R,3R,4R,5R,6S)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxy}oxacyclotetradecane-2,10-dione propanoate
EINECS	Contact for details

Quality Control

Our Josamycin Propionate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure it meets exacting standards suitable for pharmaceutical intermediate use. Certificates of Analysis (COA) documenting full specifications are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.