Description

5-Bromo-1-Chloro-3-Fluoro-2-Iodobenzene is a highly functionalized, multi-halogenated benzene derivative that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an exceptionally versatile scaffold for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require precise, high-purity intermediates for coupling reactions and structure-activity relationship (SAR) studies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially for coupling reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination to create novel therapeutic agents.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and pesticides, where the halogen atoms provide sites for further functionalization to tune biological activity.
• Material Science: Serves as a monomer or building block for creating specialized polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Employed in palladium-catalyzed cross-coupling reactions to introduce the aryl halide moiety into larger, more complex molecular architectures.
• Life Science Reagents: Utilized in the preparation of biochemical probes, fluorescent tags, and other diagnostic reagents where a stable, halogenated aromatic core is required.
• Academic & R&D: A valuable compound for methodological development in organic chemistry and for exploring new reaction pathways in research laboratories.

Basic Information

Product Name	5-Bromo-1-Chloro-3-Fluoro-2-Iodobenzene
CAS No.	83027-73-0
Molecular Formula	C6H2BrClFI
Molecular Weight	335.34 g/mol
Synonyms	1-Bromo-3-Chloro-5-Fluoro-2-Iodobenzene; 2-Iodo-5-Bromo-1-Chloro-3-Fluorobenzene; Benzene, 1-bromo-3-chloro-5-fluoro-2-iodo-; 3-Chloro-5-fluoro-2-iodobromobenzene; 5-Bromo-3-chloro-1-fluoro-2-iodobenzene (isomer); BCFI-Benzene (abbrev.)
EINECS	Contact for details

Quality Control

Our 5-Bromo-1-Chloro-3-Fluoro-2-Iodobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%
Solubility	Soluble in common organic solvents (DMSO, DMF, THF)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.