Description

(R)-Tomoxetine CAS NO 83015-26-3 is the single enantiomer form of the selective norepinephrine reuptake inhibitor, tomoxetine. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure pharmaceuticals. It is primarily utilized by pharmaceutical R&D laboratories and manufacturers specializing in advanced active pharmaceutical ingredients (APIs) for central nervous system (CNS) applications.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of enantiopure Atomoxetine (Strattera®) and related therapeutic compounds.
• Neurological Research: Used in preclinical and clinical studies to investigate the specific pharmacological activity of the (R)-enantiomer.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Process Chemistry Development: Employed in the development and optimization of asymmetric synthesis routes and chiral separation techniques.
• API Manufacturing: An essential starting material or intermediate in the cGMP production of targeted norepinephrine reuptake inhibitors.

Basic Information

Product Name	(R)-Tomoxetine
CAS No.	83015-26-3
Molecular Formula	C17H21NO
Molecular Weight	255.36 g/mol
Synonyms	(R)-N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine; (R)-Tomoxetine Hydrochloride (salt form); (R)-Fluoxetine analog; (R)-LY139603; (R)-Methylphenethylamine derivative; (R)- enantiomer of Atomoxetine precursor; (-)-(R)-Tomoxetine
EINECS	Contact for details

Quality Control

Our (R)-Tomoxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.