Description

Rac Atomoxetine Hydrochloride CAS NO 82857-40-7 is a key pharmaceutical intermediate and reference standard, specifically the racemic mixture of the selective norepinephrine reuptake inhibitor atomoxetine. This compound is of critical importance for research, development, and quality control processes within the pharmaceutical industry. It is primarily utilized by pharmaceutical manufacturers, analytical laboratories, and R&D institutions involved in the synthesis and testing of central nervous system (CNS) active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of the active pharmaceutical ingredient (API) Atomoxetine Hydrochloride.
• Analytical Reference Standard: Used as a certified reference material (CRM) for method development, validation, and quality control testing in HPLC, GC, and other analytical techniques.
• Pharmacological Research: Employed in preclinical studies to investigate the pharmacological profile, metabolism, and structure-activity relationships (SAR) of norepinephrine reuptake inhibitors.
• Impurity Profiling: Essential for identifying and quantifying related substances and enantiomeric impurities during API manufacturing to ensure final product purity and safety.
• Process Development & Optimization: Used in scaling up and optimizing synthetic routes for Atomoxetine production in pilot plants and commercial manufacturing.
• Regulatory Submissions: Provides necessary data and materials for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).

Basic Information

Item	Detail
Product Name	Rac Atomoxetine Hydrochloride
CAS No.	82857-40-7
Molecular Formula	C17H21NO • HCl
Molecular Weight	291.82 g/mol
Synonyms	(±)-Atomoxetine Hydrochloride; (R,S)-Atomoxetine HCl; N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine Hydrochloride; LY139603; Tomoxetine Hydrochloride; (RS)-Atomoxetine Hydrochloride; Racemic Atomoxetine HCl
EINECS	Contact for details

Quality Control

Our Rac Atomoxetine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, assay, impurity profiling, and residual solvent analysis, to ensure it meets high-purity standards suitable for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.