Description

Ent S-(+)-Atomoxetine Hydrochloride is the single enantiomer form of the selective norepinephrine reuptake inhibitor atomoxetine. This high-purity enantiomer is critical for research and development in neuropharmacology, offering precise targeting for studies on attention-deficit/hyperactivity disorder (ADHD) and related neurological pathways. It is an essential reference standard and key intermediate for pharmaceutical companies, academic research institutions, and contract development and manufacturing organizations (CDMOs) focused on chiral drug development and analytical method validation.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the identification, assay, and impurity profiling of atomoxetine-based drug products in quality control laboratories.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical chiral building block in the synthesis of the final drug substance for ADHD medications.
• Metabolite and Pharmacokinetic Studies: Employed in preclinical and clinical research to investigate drug metabolism, distribution, and enantiomer-specific activity.
• Analytical Method Development: Essential for developing and validating chiral separation methods using techniques like HPLC and CE.
• Neuropharmacology Research: Used in vitro and in vivo studies to elucidate the specific mechanisms of norepinephrine reuptake inhibition.
• Formulation Development: Aids in the development of stable and bioavailable dosage forms during pre-formulation studies.

Basic Information

Product Name	Ent S-(+)-Atomoxetine Hydrochloride
CAS No.	82857-39-4
Molecular Formula	C17H21NO • HCl
Molecular Weight	291.82 g/mol (Free base: 255.36)
Synonyms	(S)-Atomoxetine Hydrochloride; (S)-(+)-Tomoxetine Hydrochloride; (S)-N-Methyl-3-phenyl-3-(o-tolyloxy)propylamine Hydrochloride; LY139603; (S)-Methyl-3-phenyl-3-(2-methylphenoxy)-propylamine Hydrochloride; (S)-Atomoxetine HCl; (S)-Atomoxetine Hydrochloride; S(+)-Atomoxetine HCl
EINECS	Contact for details

Quality Control

Our Ent S-(+)-Atomoxetine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.