Description

2,4-Bis(Methylthio)-1,3,2,4-Dithiadiphosphetane-2,4-Disulfide is a specialized organosulfur and organophosphorus compound, known commercially as Lawesson's Reagent. This chemical is a powerful and versatile reagent for the thionation of carbonyl groups, converting amides, esters, and ketones into their corresponding thio-analogs. It is an essential tool for synthetic organic chemists and process development teams in the pharmaceutical, agrochemical, and advanced materials sectors, enabling the synthesis of complex sulfur-containing molecules. The compound is supplied with CAS number 82737-61-9.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of thioamides and thioketones, which are crucial scaffolds in drug discovery and active pharmaceutical ingredients (APIs).
• Agrochemical Production: Used in the synthesis of sulfur-containing pesticides, herbicides, and fungicides, enhancing product efficacy and stability.
• Material Science Research: Facilitates the creation of novel heterocyclic compounds and ligands for catalysis, as well as precursors for electronic materials.
• Organic Synthesis & Methodology Development: A staple reagent in research laboratories for the transformation of carbonyl functionalities, enabling new synthetic routes.
• Flavor & Fragrance Industry: Employed in the synthesis of sulfur-containing aroma compounds that contribute to savory or roasted notes.

Basic Information

Product Name	2,4-Bis(Methylthio)-1,3,2,4-Dithiadiphosphetane-2,4-Disulfide
CAS No.	82737-61-9
Molecular Formula	C4H12P2S6
Molecular Weight	348.44 g/mol
Synonyms	Lawesson's Reagent; 2,4-Bis(4-methoxyphenyl)-1,3,2,4-dithiadiphosphetane 2,4-disulfide (common misnomer); LR; 2,4-Bis(methylthio)-2,4-dithio-1,3,2,4-dithiadiphosphetane; Tetrathiafulvalene precursor reagent; Dithiadiphosphetane disulfide derivative; Bis(methylthio)thionation reagent
EINECS	Contact for details

Quality Control

Our 2,4-Bis(Methylthio)-1,3,2,4-Dithiadiphosphetane-2,4-Disulfide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and performance in standard thionation reactions. A comprehensive Certificate of Analysis (COA) detailing assay, impurity profile, and physical characteristics is provided with every shipment. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. This compound is easily oxidized and should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat and moisture sources.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	228 - 232 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.