Description

1-[3-(Difluoromethoxy)Phenyl]-1H-Pyrrole-2,5-Dione is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique difluoromethoxy-substituted phenylpyrrole structure imparts desirable biological and physicochemical properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries seeking to innovate new molecular entities.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides and fungicides, leveraging the bioactivity of the pyrrole-2,5-dione core.
• Material Science Research: Serves as a monomer or precursor for developing specialized polymers and advanced organic electronic materials.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects requiring this precise scaffold.

Basic Information

Product Name	1-[3-(Difluoromethoxy)Phenyl]-1H-Pyrrole-2,5-Dione
CAS No.	82673-81-2
Molecular Formula	C11H7F2NO3
Molecular Weight	239.18 g/mol
Synonyms	3-(Difluoromethoxy)phenylmaleimide; 1-[3-(Difluoromethoxy)phenyl]-1H-pyrrole-2,5-dione; 1H-Pyrrole-2,5-dione, 1-[3-(difluoromethoxy)phenyl]-; N-[3-(Difluoromethoxy)phenyl]maleimide; 3-(Difluoromethoxy)phenylmaleimide; Maleimide, N-[3-(difluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our 1-[3-(Difluoromethoxy)Phenyl]-1H-Pyrrole-2,5-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.