Description

1-(4-Fluorophenyl)-2-(Methylsulfonyl)-1-Ethanone CAS NO 82652-17-3 is a high-purity, specialized organic building block featuring a fluorinated aromatic ring and a methylsulfonyl ketone functional group. This compound is valued for its role as a critical intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the fluorine atom and sulfone group contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, where its structural motifs can influence material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, nucleophilic additions, and other transformations to introduce the 4-fluorophenyl and methylsulfonylacetyl motifs into target molecules.
• Biochemical Tool Compound: Potential use in developing enzyme inhibitors or probes for biochemical assays due to its specific electronic and steric profile.

Basic Information

Product Name	1-(4-Fluorophenyl)-2-(Methylsulfonyl)-1-Ethanone
CAS No.	82652-17-3
Molecular Formula	C9H9FO3S
Molecular Weight	216.23 g/mol
Synonyms	4'-Fluoro-2-(methylsulfonyl)acetophenone; 2-(Methylsulfonyl)-1-(4-fluorophenyl)ethanone; 1-(4-Fluorophenyl)-2-(methylsulfonyl)ethanone; 4-Fluorophenyl methylsulfonyl ketone; p-Fluorophenyl methylsulfonyl ketone; 82652-17-3; 1-(4-Fluorophenyl)-2-methanesulfonyl-ethanone
EINECS	Contact for details

Quality Control

Our 1-(4-Fluorophenyl)-2-(Methylsulfonyl)-1-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.