Description

1-Phenyl-2-[4-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Phenyl]-1-Butanone is a high-value, protected intermediate featuring a versatile tetrahydro-2H-pyran-2-yl (THP) ether group. This compound is critical for synthetic chemists as the THP protecting group shields reactive hydroxyl functionalities during multi-step synthesis, enabling the precise construction of complex molecules. It is primarily utilized in the research and development of pharmaceuticals and advanced organic materials, where controlled deprotection is required.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring selective deprotection strategies.
• Organic Synthesis Research: Used extensively in academic and industrial R&D labs for constructing complex molecular architectures, including natural products and specialty chemicals.
• Agrochemical Development: Acts as a precursor in the synthesis of novel crop protection agents and herbicides where the THP group offers synthetic flexibility.
• Material Science: Employed in the development of specialty polymers and advanced organic electronic materials that require protected functional groups during polymerization.
• Chemical Biology Probes: Utilized in the creation of molecular probes and diagnostics where temporary protection of hydroxyl groups is necessary for labeling or conjugation.

Basic Information

Item	Details
Product Name	1-Phenyl-2-[4-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Phenyl]-1-Butanone
CAS No.	82413-31-8
Molecular Formula	C21H24O3
Molecular Weight	324.42 g/mol
Synonyms	1-Phenyl-2-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]-1-butanone; 1-Butanone, 1-phenyl-2-[4-[(tetrahydro-2H-pyran-2-yl)oxy]phenyl]-; THP-protected ketone intermediate; 4'-(Tetrahydro-2H-pyran-2-yloxy)desoxybenzoin derivative; 2-[4-(Oxan-2-yloxy)phenyl]-1-phenylbutan-1-one; 82413-31-8; Ketone, THP-protected hydroxy phenyl
EINECS	Contact for details

Quality Control

Our 1-Phenyl-2-[4-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]Phenyl]-1-Butanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.