Description

Sergeolide is a specialized sesquiterpene lactone derivative widely recognized for its potent biological activity and structural utility in synthetic chemistry. It serves as a critical intermediate in the development of anti-inflammatory, anticancer, and antimicrobial agents—delivering high selectivity and reproducible performance in complex multi-step syntheses. Pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) rely on Sergeolide CAS NO 82290-17-3 for scalable, GMP-aligned process development and preclinical candidate optimization.

Application

• Key chiral building block in the synthesis of novel antitumor agents targeting NF-κB and STAT3 pathways
• Intermediate in the production of semi-synthetic analogues for structure–activity relationship (SAR) studies
• Substrate for enzymatic and asymmetric catalytic transformations in green pharmaceutical manufacturing
• Reference standard and calibration material for HPLC and LC-MS quantification in pharmacokinetic studies
• Tool compound in mechanistic cell biology research investigating apoptosis induction and oxidative stress response
• Starting material for radiolabeled tracer synthesis (e.g., 14C- or 3H-labeled derivatives)

Basic Information

Product Name	Sergeolide
CAS No.	82290-17-3
Molecular Formula	C15H18O4
Molecular Weight	262.30 g/mol
Synonyms	3α,8α-Dihydroxy-6β-methoxy-4(15),10(14)-germacradien-12-oic acid δ-lactone; 3α,8α-Dihydroxy-6β-methoxygermacra-4(15),10(14)-dien-12-oic acid lactone; NSC 634231; Germacranolide derivative; 6β-Methoxy-3α,8α-dihydroxygermacra-4(15),10(14)-dien-12-oic acid γ-lactone; 3α,8α-Dihydroxy-6β-methoxy-4(15),10(14)-germacradien-12-oic acid lactone; Sergeolide lactone; 82290-17-3 (CAS)
EINECS	Not listed

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request. All batches conform to stringent specifications for identity, assay, residual solvents, heavy metals (<5 ppm), and microbial limits (where applicable). Testing includes HPLC purity determination, IR and NMR spectral verification, chiral purity assessment (if relevant), and residual moisture analysis (Karl Fischer). Manufactured under ISO 9001-certified processes; compliant with REACH and ICH Q5/Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at 2–8 °C under inert atmosphere (nitrogen or argon) to prevent degradation. Keep away from heat, moisture, and strong oxidizing agents. Ensure adequate ventilation in storage areas.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Odor	Characteristic mild odor
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Single impurity ≤ 0.3%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C Class 3 limits
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.