Description

n-Carbobenzoxypyroglutamyl Diazomethyl Ketone is a specialized diazo compound used as a key synthetic intermediate in advanced organic synthesis. Its primary value lies in its role as a versatile building block for constructing complex molecules, particularly in the development of novel pharmaceuticals and bioactive compounds. This product is essential for research chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries who require high-purity intermediates for peptide and heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of protease inhibitors and other targeted therapeutic agents.
• Peptide Chemistry: Used in the preparation of modified peptides and peptidomimetics, leveraging the reactivity of the diazomethyl ketone group.
• Chemical Biology Probes: Serves as a key component for creating activity-based probes to study enzyme function and mechanism.
• Heterocyclic Compound Synthesis: Employed in the construction of complex nitrogen-containing heterocycles, which are common scaffolds in medicinal chemistry.
• Cross-linking Agent: Potential use in the development of novel cross-linking reagents for protein and biomaterial studies.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.

Basic Information

Product Name	n-Carbobenzoxypyroglutamyl Diazomethyl Ketone
CAS No.	81910-23-8
Molecular Formula	C16H17N3O5
Molecular Weight	331.33 g/mol
Synonyms	CBZ-Pyroglutamyl Diazomethyl Ketone; N-Cbz-L-pyroglutamyl diazomethyl ketone; (S)-1-(((Benzyloxy)carbonyl)-5-oxopyrrolidine-2-carbonyl)diazomethane; 2-[(Benzyloxycarbonyl)amino]-5-diazo-4-oxopentanoic acid γ-lactone; Z-Pyroglutamyl-CHN2; Z-5-Oxo-Pro-CHN2; Diazomethyl ketone of N-carbobenzoxypyroglutamic acid
EINECS	Contact for details

Quality Control

Our n-Carbobenzoxypyroglutamyl Diazomethyl Ketone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.