Description

Dde I is a specialized chemical reagent widely used in advanced organic synthesis and bioconjugation strategies. Its primary value lies in its role as a versatile protecting group for amines, offering excellent orthogonality and stability under various reaction conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors, particularly for the synthesis of complex peptides, oligonucleotides, and other sensitive biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an orthogonal amine-protecting group, enabling the sequential assembly of complex peptides.
• Oligonucleotide Synthesis: For the protection of exocyclic amino groups on nucleobases during automated DNA/RNA synthesis.
• Bioconjugation and Linker Chemistry: Facilitating the site-specific attachment of labels, drugs, or other functional moieties to biomolecules.
• Combinatorial Chemistry Library Production: Allowing for the generation of diverse compound libraries through selective deprotection and functionalization.
• Glycopeptide and Glycoprotein Synthesis: Protecting amino functionalities during the challenging synthesis of glycosylated biomolecules.
• Intermediate for Advanced Materials: Serving as a building block in the development of specialized polymers and functional surfaces.

Basic Information

Product Name	Dde I
CAS No.	81811-53-2
Molecular Formula	C12H11NO3
Molecular Weight	217.22 g/mol
Synonyms	1-(4,4-Dimethyl-2,6-dioxocyclohex-1-ylidene)-3-methylbutyl; 1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl; Dde-OH; N-(1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl); 4,4-Dimethyl-2,6-dioxocyclohexylidene Derivative; N-Dde Protecting Group Reagent; Dde Protecting Group
EINECS	Contact for details

Quality Control

Our Dde I is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and production applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.