Description

Lolitrem B is a potent tremorgenic mycotoxin belonging to the indole-diterpene class of secondary metabolites. This compound is of significant interest in veterinary and agricultural research due to its role in causing ryegrass staggers, a neurological disorder in grazing livestock. It serves as a critical reference standard and research material for scientists and quality control laboratories. Key users include analytical chemists, toxicologists, and agri-safety professionals focused on mycotoxin detection, food/feed safety, and the study of neurological toxins.

Application

• Veterinary Toxicology Research: Primary reference material for studying the pathophysiology and diagnosis of ryegrass staggers in animals.
• Agricultural & Feed Safety: Analytical standard for the detection and quantification of Lolitrem B in pasture grasses, hay, and animal feedstuffs to ensure safety.
• Mycotoxin Analysis: Certified reference standard for calibrating equipment (HPLC, LC-MS) and validating analytical methods in food and environmental testing laboratories.
• Pharmacological Studies: Research tool for investigating the mechanism of action of tremorgenic neurotoxins on ion channels and neuronal signaling.
• Quality Control & Manufacturing: Used by manufacturers of diagnostic kits and immunoassays for mycotoxin detection as a critical quality control component.
• Academic Research: Standard for biochemical and chemical research exploring the biosynthesis, structure-activity relationships, and environmental fate of indole-diterpenes.

Basic Information

Product Name	Lolitrem B
CAS No.	81771-19-9
Molecular Formula	C42H55NO7
Molecular Weight	685.9 g/mol
Synonyms	Lolitrem B; Lolitriol; 6,7-Epoxylolitrem B; Tremorgenic Mycotoxin Lolitrem B; Indole-diterpene Lolitrem B; (1R,2S,5S,7R,10R,11R,14S,15S,17S,20S,24S,26R,30S,32S,33R,35R,36S,37S,39R,41R,42S,44S,46R,48S,49S,51R,52S,54S,55R,57S,59R,60S,62S,63R,65S,67R,68S,70S,71R,73S,75R,76S,78S,79R,81S,83R,84S,86S,87R,89S,91R,92S,94S,95R,97S,99R)-42-[(2S,4S,5S)-5-Ethyl-4-hydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-1-benzazocin-3-yl]-5,6,8,11,12,14,15,17,20,21,23,24,26,27,29,30,32,33,35,36,38,39,41,42,44,45,47,48,50,51,53,54,56,57,59,60,62,63,65,66,68,69,71,72,74,75,77,78,80,81,83,84,86,87,89,90,92,93,95,96,98,99-hexacontahydro-1H-1,10:4,5-dietheno-2,7-methanoazuleno[4,5-f]azuleno[3',2':18,19][1,6]dioxacyclooctadecino[11,12-b]indole-3,9,16,22,28,34,40,46,52,58,64,70,76,82,88,94-hexadecol
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Quality Control

Our Lolitrem B is produced and handled under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research and analytical applications. Each batch undergoes comprehensive analysis using advanced techniques such as HPLC and mass spectrometry. A detailed Certificate of Analysis (COA), providing full characterization data including purity, identity confirmation, and impurity profile, is supplied with every shipment to guarantee traceability and meet the stringent requirements of research and quality control laboratories.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with reference
Purity (HPLC)	≥ 95% (Area Percent)
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.