Description

α-Monofluoromethyltyrosine Methyl Ester is a fluorinated tyrosine derivative, a key synthetic intermediate in advanced pharmaceutical research and development. This compound is valued for its role in modulating biological activity through the strategic introduction of fluorine, which can enhance metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and research organizations in the development of novel enzyme inhibitors, targeted therapeutics, and positron emission tomography (PET) radiotracer precursors.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of fluorinated drug candidates targeting various disease pathways.
• Enzyme Inhibitor Development: Used in research to create potent and selective inhibitors for tyrosine-utilizing enzymes.
• PET Tracer Precursor: Serves as a precursor molecule for the radiosynthesis of fluorine-18 labeled compounds used in diagnostic imaging.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to investigate the effects of fluorination on pharmacokinetic properties.
• Biochemical Probe Synthesis: Utilized to create labeled or modified probes for studying biological processes and protein interactions.
• Academic & Institutional R&D: Supports basic and applied research in chemical biology and organic synthesis at universities and research institutes.

Basic Information

Product Name	α-Monofluoromethyltyrosine Methyl Ester
CAS No.	81363-78-2
Molecular Formula	C12H15FNO4
Molecular Weight	256.25 g/mol
Synonyms	L-Tyrosine, α-(fluoromethyl)-, methyl ester; (2S)-2-Amino-3-(4-hydroxyphenyl)-2-(fluoromethyl)propanoic acid methyl ester; Methyl (2S)-2-amino-3-(4-hydroxyphenyl)-2-(fluoromethyl)propanoate; α-Fluoromethyltyrosine methyl ester; FMTyr-OMe; FM-Tyr-OMe; Monofluoromethyltyrosine methyl ester
EINECS	Contact for details

Quality Control

Our α-Monofluoromethyltyrosine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure it meets the exacting standards required for research and development. A Certificate of Analysis (COA) detailing identity, purity, and specific test results is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.