Description

3-(Trifluoromethyl)-3-(3-Iodophenyl)Diazirine is a specialized diazirine-based photoaffinity labeling reagent, a critical tool for studying biomolecular interactions and mapping binding sites. Its core value lies in its ability to form highly reactive carbene intermediates upon photolysis, enabling covalent cross-linking to target proteins or nucleic acids for structural analysis. This compound is essential for researchers and developers in pharmaceutical discovery, chemical biology, and proteomics who require precise, irreversible labeling to elucidate complex biological mechanisms.

Application

• Photoaffinity Labeling (PAL): A key reagent for covalent cross-linking in the study of protein-ligand, protein-protein, and protein-nucleic acid interactions.
• Chemical Biology & Proteomics: Used to identify and characterize drug targets, map binding sites, and discover new bioactive molecules.
• Pharmaceutical R&D: Employed in the development of novel therapeutics by enabling the study of drug action mechanisms and off-target effects.
• Bioconjugation & Probe Synthesis: Serves as a versatile building block for synthesizing advanced molecular probes and diagnostic agents.
• Material Science Research: Applied in surface functionalization and the development of photoactive polymers or coatings.

Basic Information

Product Name	3-(Trifluoromethyl)-3-(3-Iodophenyl)Diazirine
CAS No.	81340-56-9
Molecular Formula	C8H4F3IN2
Molecular Weight	312.03 g/mol
Synonyms	3-(3-Iodophenyl)-3-(trifluoromethyl)diazirine; 3-Iodo-α,α,α-trifluoro-m-tolyldiazirine; 3-Iodo-α,α,α-trifluoro-3H-diazirin-3-ylbenzene; TID; 3-(Trifluoromethyl)-3-(3-iodophenyl)diaziridine (photoaffinity label); Photoaffinity Labeling Reagent TID; m-Iodo-α,α,α-trifluorotolyldiazirine
EINECS	Contact for details

Quality Control

We supply 3-(Trifluoromethyl)-3-(3-Iodophenyl)Diazirine in high-purity grades suitable for sensitive research applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Keep away from heat, sparks, and open flame. For long-term stability, consider storage at -20°C.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Melting Point	Contact for details
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.