Description

(R)-2-Methyloxetane CAS NO 81244-76-0 is a high-purity, chiral oxetane building block of significant importance in modern synthetic chemistry. Its value lies in its ability to introduce the oxetane moiety, a valuable isostere for carbonyl and gem-dimethyl groups, into complex molecules, thereby modulating their physicochemical and metabolic properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of new active ingredients, particularly for creating novel prodrugs and improving the pharmacokinetic profiles of lead compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in antiviral and anticancer drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the oxetane ring can enhance biological activity and environmental stability.
• Material Science Monomer: Serves as a precursor for specialized polymers and resins, contributing to unique material properties like solubility and thermal stability.
• Ligand and Catalyst Development: Employed in the construction of chiral ligands and organocatalysts for asymmetric synthesis.
• Prodrug Design: Utilized to create bioreversible derivatives of drug molecules to improve bioavailability, taste masking, or targeted delivery.
• Chemical Biology Probes: Acts as a versatile handle for labeling and modifying biomolecules in proteomics and diagnostic research.

Basic Information

Product Name	(R)-2-Methyloxetane
CAS No.	81244-76-0
Molecular Formula	C4H8O
Molecular Weight	72.11 g/mol
Synonyms	(R)-2-Methyloxacyclobutane; (R)-2-Methyl-1,3-propylene oxide; (R)-2-Methyloxetane; (R)-Oxetane, 2-methyl-; (2R)-2-Methyloxetane; (R)-(-)-2-Methyloxetane; (R)-2-Methyl-oxetane; (R)-2-Methyloxetan
EINECS	Contact for details

Quality Control

Our (R)-2-Methyloxetane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by GC or HPLC, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at recommended room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed and away from heat, sparks, and open flame. For long-term storage, consider keeping under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Enantiomeric Excess (Chiral GC/HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.