Description

1-[4-(Trifluoromethyl)Phenyl]But-1-En-3-One is a specialized fluorinated organic building block characterized by its α,β-unsaturated ketone (enone) functionality attached to a trifluoromethylphenyl group. This unique molecular architecture makes it a valuable intermediate for synthesizing complex molecules where the trifluoromethyl group is desired to modulate lipophilicity, metabolic stability, and binding affinity. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing the metabolically stable trifluoromethyl group into lead compounds.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorinated moiety can enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for developing specialty polymers, liquid crystals, or organic electronic materials with tailored properties.
• Chemical Research & Development: Employed in organic synthesis for Michael addition reactions, cyclizations, and other transformations to construct complex heterocyclic or fluorinated structures.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research focused on the reactivity and applications of fluorinated aromatic systems.

Basic Information

Product Name	1-[4-(Trifluoromethyl)Phenyl]But-1-En-3-One
CAS No.	80992-93-4
Molecular Formula	C11H9F3O
Molecular Weight	214.18 g/mol
Synonyms	4'-(Trifluoromethyl)chalcone; 3-Buten-2-one, 1-[4-(trifluoromethyl)phenyl]-; 1-[4-(Trifluoromethyl)phenyl]-3-buten-2-one; (E)-1-[4-(Trifluoromethyl)phenyl]but-2-en-1-one; 4-Trifluoromethylchalcone; p-Trifluoromethylchalcone; 4'-Trifluoromethylchalcone
EINECS	Contact for details

Quality Control

Our 1-[4-(Trifluoromethyl)Phenyl]But-1-En-3-One is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research and industrial use. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.