Description

(R)-(-)-4-Methylglutaric Acid 1-Monomethyl Ester is a high-purity chiral building block and synthetic intermediate of significant importance in advanced organic synthesis. Its value lies in its defined stereochemistry, which is critical for producing enantiomerically pure compounds in pharmaceutical and fine chemical research. This product is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications such as asymmetric synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the asymmetric synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Synthesis: Serves as a versatile building block for creating specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry, particularly in catalysis and stereoselective transformations.
• Ligand and Catalyst Preparation: Can be utilized in the synthesis of chiral ligands and organocatalysts for asymmetric reactions.

Basic Information

Product Name	(R)-(-)-4-Methylglutaric Acid 1-Monomethyl Ester
CAS No.	80986-17-0
Molecular Formula	C8H14O4
Molecular Weight	174.19 g/mol
Synonyms	(R)-4-Methylglutaric Acid 1-Monomethyl Ester; (R)-(-)-Monomethyl 4-Methylglutarate; (R)-Methyl Hydrogen 4-Methylglutarate; (R)-1-Methoxy-4-methyl-1,5-pentanedioic Acid 5-Ethyl Ester (common misnomer); (R)-4-Methylpentanedioic Acid 1-Methyl Ester; (R)-Methyl 4-Methylglutarate Half-Ester; (R)-Mono-methyl 4-methylglutarate
EINECS	Contact for details

Quality Control

Our (R)-(-)-4-Methylglutaric Acid 1-Monomethyl Ester is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, NMR, and IR for structural confirmation. Certificates of Analysis (COA) detailing purity, assay, and specific rotation are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to minimize exposure to moisture and strong bases or organic solvents, as indicated by its chemical properties.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.