Description

5-(2-Fluorophenyl)-2-piperidone is a specialized fluorinated heterocyclic compound that serves as a critical building block in advanced organic synthesis. Its value lies in its unique piperidone core functionalized with a fluorinated aromatic ring, making it a versatile intermediate for constructing complex molecular architectures. This high-purity intermediate is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom can enhance biological activity and metabolic stability.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Ligand and Catalyst Preparation: Utilized in the synthesis of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Precursor: Acts as a monomer or functional additive in the development of specialty polymers and advanced organic materials.

Basic Information

Product Name	5-(2-Fluorophenyl)-2-piperidone
CAS No.	80942-15-0
Molecular Formula	C11H12FNO
Molecular Weight	193.22 g/mol
Synonyms	2-Fluoro-α-(2-oxo-1-piperidinyl)benzeneacetonitrile; 5-(2-Fluorophenyl)piperidin-2-one; 2-Piperidone, 5-(2-fluorophenyl)-; 2-Fluorophenylpiperidone; α-(2-Oxo-1-piperidinyl)-2-fluorobenzeneacetonitrile; 5-(o-Fluorophenyl)-2-piperidone; 80942-15-0; 5-(2-Fluorophenyl)-delta2-piperidone
EINECS	Contact for details

Quality Control

Our 5-(2-Fluorophenyl)-2-piperidone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.