Description

(2S,5S)-3'Aα,4,4',5,5',6',7',7'A-Octahydro-4',4',5,7'Aβ-Tetramethyl-3'α-(2-Oxopropyl)Spiro[Furan-2(3H),1'(3'H)-Isobenzofuran]-5-Acetic Acid is a high-purity, complex spirocyclic compound with significant potential as a key chiral intermediate in advanced organic synthesis. Its intricate molecular architecture, featuring fused furan and isobenzofuran rings, makes it a valuable building block for constructing sophisticated pharmacophores and specialty chemicals. This compound is primarily sought by research institutions and pharmaceutical developers for the synthesis of novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new therapeutic agents, particularly for complex small-molecule drugs.
• Agrochemical Synthesis: Used in the production of advanced, stereospecific pesticides and herbicides where biological activity is highly structure-dependent.
• Organic Synthesis Research: Acts as a versatile scaffold in academic and industrial R&D for exploring new chemical spaces and reaction methodologies.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, including flavors, fragrances, and advanced materials requiring specific stereochemical configurations.
• Catalyst & Ligand Development: Potential precursor for developing novel chiral catalysts or ligands used in asymmetric synthesis.

Basic Information

Product Name	(2S,5S)-3'Aα,4,4',5,5',6',7',7'A-Octahydro-4',4',5,7'Aβ-Tetramethyl-3'α-(2-Oxopropyl)Spiro[Furan-2(3H),1'(3'H)-Isobenzofuran]-5-Acetic Acid
CAS No.	80865-69-6
Molecular Formula	C21H30O5
Molecular Weight	362.46 g/mol
Synonyms	Spiro[Furan-2(3H),1'(3'H)-Isobenzofuran]-5-acetic acid, 3'Aα,4,4',5,5',6',7',7'A-octahydro-4',4',5,7'Aβ-tetramethyl-3'α-(2-oxopropyl)-, (2S,5S)-; (2S,5S)-Spirofuran-isobenzofuran acetic acid derivative; CAS 80865-69-6; 3'α-(2-Oxopropyl)spirofuran-isobenzofuran acetic acid; (2S-cis)-rel-(+)-3'Aα,4,4',5,5',6',7',7'A-Octahydro-4',4',5,7'Aβ-tetramethyl-3'α-(2-oxopropyl)spiro[furan-2(3H),1'(3'H)-isobenzofuran]-5-acetic acid
EINECS	Contact for details

Quality Control

Our (2S,5S)-3'Aα,4,4',5,5',6',7',7'A-Octahydro-4',4',5,7'Aβ-Tetramethyl-3'α-(2-Oxopropyl)Spiro[Furan-2(3H),1'(3'H)-Isobenzofuran]-5-Acetic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat sources and incompatible materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.