Description

4,4,4-Trifluoro-1-Phenylbut-1-(E)-Ene-3-Ol is a high-value fluorinated organic intermediate characterized by a phenyl ring, a conjugated enol system, and a trifluoromethyl group. This unique structure makes it a versatile building block for synthesizing more complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of drug candidates, especially those requiring the incorporation of a trifluoromethyl group to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic semiconductors and liquid crystal compounds for display technologies.
• Specialty Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, improving their chemical resistance, thermal stability, and surface properties.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Heck, Suzuki) to construct complex biaryl systems.
• Academic & Industrial Research: A valuable reagent for exploring new fluorination methodologies and reaction pathways in synthetic organic chemistry.

Basic Information

Product Name	4,4,4-Trifluoro-1-Phenylbut-1-(E)-Ene-3-Ol
CAS No.	80768-54-3
Molecular Formula	C10H7F3O
Molecular Weight	200.16 g/mol
Synonyms	(E)-4,4,4-Trifluoro-1-phenylbut-1-en-3-ol; 4,4,4-Trifluoro-3-hydroxy-1-phenyl-1-butene; 1-Phenyl-4,4,4-trifluorobut-1-ene-3-ol; 3-Buten-3-ol, 4,4,4-trifluoro-1-phenyl-, (E)-; 4,4,4-Trifluoro-3-hydroxy-1-phenyl-1-butene (E)-isomer; α-(Trifluoromethyl)cinnamyl alcohol; (E)-α-(Trifluoromethyl)cinnamyl alcohol
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-1-Phenylbut-1-(E)-Ene-3-Ol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. We provide comprehensive analytical data including HPLC purity, NMR, and IR spectroscopy for identity confirmation. Certificates of Analysis (COA) detailing all specifications are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.