Description

2-Oxo-2-[3-(Trifluoromethoxy) Phenyl]-Acetonitrile is a versatile and high-value organic intermediate characterized by its ketone and nitrile functional groups attached to a trifluoromethoxy-substituted aromatic ring. This molecular structure makes it a critical building block for synthesizing more complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the life sciences sector for constructing novel active ingredients.

Application

This specialized intermediate serves as a key precursor in several high-tech synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediates: Core building block for the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, due to the bioactivity-enhancing trifluoromethoxy group.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy moiety can improve metabolic stability and efficacy.
• Liquid Crystal Materials: Intermediate in the production of advanced liquid crystals for display technologies, leveraging its rigid aromatic core and polarizable groups.
• Organic Electronic Materials: Serves as a precursor for electron-transport materials or small-molecule semiconductors in OLED and OPV research.
• Fluorinated Dye & Pigment Research: Used to incorporate fluorine atoms into dye and pigment structures to enhance lightfastness, chemical resistance, and color properties.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the pharmaceutical and specialty chemical industries.

Basic Information

Product Name	2-Oxo-2-[3-(Trifluoromethoxy) Phenyl]-Acetonitrile
CAS No.	80277-37-8
Molecular Formula	C10H5F3NO2
Molecular Weight	228.15 g/mol
Synonyms	3-(Trifluoromethoxy)benzoyl cyanide; 2-Oxo-2-[3-(trifluoromethoxy)phenyl]acetonitrile; [3-(Trifluoromethoxy)phenyl](oxo)acetonitrile; α-Oxo-3-(trifluoromethoxy)benzeneacetonitrile; 3-Trifluoromethoxybenzoyl cyanide; (3-Trifluoromethoxyphenyl)glyoxylonitrile; 2-Oxo-2-(3-trifluoromethoxyphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 2-Oxo-2-[3-(Trifluoromethoxy) Phenyl]-Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.