Description

Acth (1-26), Bis(Cys(25))- is a synthetic peptide fragment of the adrenocorticotropic hormone (ACTH), specifically engineered with a disulfide bridge formed by two cysteine residues at position 25. This modification enhances the structural stability of the peptide, making it a valuable tool for biochemical and pharmacological research. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for studying hormone-receptor interactions, developing diagnostic assays, and exploring therapeutic applications related to the adrenal cortex.

Application

• Biochemical Research: Used as a reference standard and active agent in studies of ACTH receptor binding, signal transduction, and steroidogenesis.
• Pharmaceutical Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the development of diagnostic kits and potential therapeutic agents targeting adrenal function.
• In Vitro Diagnostics: Employed in the calibration and quality control of immunoassays designed to measure ACTH levels in clinical samples.
• Neuroscience & Endocrinology Studies: Facilitates research into the stress response, metabolic pathways, and the hypothalamic-pituitary-adrenal (HPA) axis.
• Peptide Chemistry & Conjugation: The unique bis-cysteine structure allows for site-specific conjugation, useful in creating labeled probes or peptide-drug conjugates for targeted research.

Basic Information

Product Name	Acth (1-26), Bis(Cys(25))-
CAS No.	80208-73-7
Molecular Formula	C₁₄₆H₂₃₈N₄₄O₄₈S₂
Molecular Weight	3384.8 g/mol
Synonyms	ACTH (1-26), bis-Cys(25)-; Adrenocorticotropic Hormone (1-26), Bis(Cys(25))-; [Cys25,Cys25]-ACTH (1-26); Cosyntropin derivative; Tetracosactide hexaacetate derivative; 1-26-Corticotropin, bis-25-cysteine; Synthetic ACTH fragment (1-26) disulfide; Diagnostic peptide ACTH (1-26) bis-cysteine
EINECS	Contact for details

Quality Control

Our Acth (1-26), Bis(Cys(25))- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available upon request, detailing purity, content, and impurity profiles to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0%
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 15.0%
Single Impurity (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.