Description

Phorbol 12-Retinoate 13-Acetate, 4Beta is a highly specific and potent synthetic derivative of phorbol, a diterpene ester known for its biological activity. This compound is of significant value in biochemical and pharmacological research, particularly as a protein kinase C (PKC) activator and a tool for studying cell signaling pathways. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies for investigating tumor promotion, inflammation, and cellular differentiation mechanisms.

Application

• Biochemical Research: As a potent and specific activator of Protein Kinase C (PKC) isoforms for studying signal transduction.
• Pharmacological Studies: Used in vitro and in vivo models to investigate the role of PKC in tumor promotion, cell proliferation, and apoptosis.
• Drug Discovery: A critical reference standard and tool compound in screening assays for developing PKC-targeted therapeutics.
• Cell Biology: For probing mechanisms of cellular differentiation, inflammation, and immune response regulation.
• Academic Research: Fundamental research into diterpene ester chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	Phorbol 12-Retinoate 13-Acetate, 4Beta
CAS No.	80188-99-4
Molecular Formula	C42H56O8
Molecular Weight	688.90 g/mol
Synonyms	4β-Phorbol 12-retinoate 13-acetate; 12-Retinoylphorbol 13-acetate; 4β-Phorbol 12-(all-trans-retinoate) 13-acetate; TPA analog; Phorbol 12-retinoate 13-acetate; PKC Activator (Retinoyl); 12-O-Retinoylphorbol-13-acetate; 4β-Phorbol-12-retinoate-13-acetate
EINECS	Contact for details

Quality Control

Our Phorbol 12-Retinoate 13-Acetate, 4Beta is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is light-sensitive (store away from light). Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.