Description

1-Chloro-2-Ethynylbenzene is a versatile aromatic alkyne building block characterized by its reactive ethynyl and chloro substituents. This compound is essential for advanced organic synthesis, enabling the construction of complex molecular architectures through cross-coupling and cycloaddition reactions. It is primarily sought after by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and materials science sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon for constructing bioactive molecules and active pharmaceutical ingredients (APIs) via Sonogashira and other metal-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators.
• Material Science Research: Serves as a monomer or precursor for synthesizing conjugated polymers, organic semiconductors, and advanced resins.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, including [2+2] and other cycloadditions.
• Fine Chemical Production: Intermediate in the multi-step synthesis of dyes, flavors, and fragrances.

Basic Information

Product Name	1-Chloro-2-Ethynylbenzene
CAS No.	873-31-4
Molecular Formula	C8H5Cl
Molecular Weight	136.58 g/mol
Synonyms	2-Chlorophenylacetylene; o-Chlorophenylacetylene; (2-Chlorophenyl)ethyne; 1-Chloro-2-ethynyl-benzene; 2-Ethynylchlorobenzene; Benzene, 1-chloro-2-ethynyl-; 873-31-4; NSC 406908
EINECS	212-849-9

Quality Control

Our 1-Chloro-2-Ethynylbenzene is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Clear colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.