Description

5-Fluoro-2,3-Dihydro-2-Methyl-1H-Indole is a high-purity, versatile heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its indoline scaffold substituted with fluorine and a methyl group, making it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it serves as a key precursor for active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluorinated indoline structure.
• Material Science Research: Serves as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a molecular scaffold or tag in the design of chemical probes and enzyme inhibitors for biological studies.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	5-Fluoro-2,3-Dihydro-2-Methyl-1H-Indole
CAS No.	825-70-7
Molecular Formula	C9H10FN
Molecular Weight	151.18 g/mol
Synonyms	2-Methyl-5-fluoroindoline; 5-Fluoro-2-methylindoline; 5-Fluoro-2-methyl-2,3-dihydro-1H-indole; 1H-Indole, 5-fluoro-2,3-dihydro-2-methyl-; 825-70-7; FChem; 5-F-2-MI
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2,3-Dihydro-2-Methyl-1H-Indole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production can adhere to cGMP and ISO 9001 standards to meet the stringent requirements of pharmaceutical and fine chemical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storage under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.