Description

Diethyl (3,3-Dimethyl-2-Oxobutyl)Phosphonate is a high-value organophosphorus compound, specifically a phosphonate ester, widely recognized as a key Horner-Wadsworth-Emmons (HWE) reagent. Its primary commercial value lies in its exceptional utility as a stable carbanion equivalent for the synthesis of α,β-unsaturated carbonyl compounds, offering advantages in stereoselectivity and yield over other methods. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries engaged in the development of complex molecules, including APIs, fragrances, and advanced materials.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent in the Horner-Wadsworth-Emmons (HWE) olefination reaction for constructing carbon-carbon double bonds in drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the production of advanced pesticides, herbicides, and plant growth regulators that require specific alkene geometries.
• Fine Chemical & Fragrance Production: Enables the synthesis of specific isomers of unsaturated aldehydes, ketones, and esters used in flavors, fragrances, and specialty chemicals.
• Material Science Research: Serves as a building block for creating novel organic frameworks, polymers, and liquid crystals with tailored properties.
• Academic & R&D Laboratories: A staple reagent in synthetic organic chemistry for method development and the exploration of new reaction pathways.

Basic Information

Product Name	Diethyl (3,3-Dimethyl-2-Oxobutyl)Phosphonate
CAS No.	814-16-4
Molecular Formula	C10H21O4P
Molecular Weight	236.24 g/mol
Synonyms	Diethyl (3,3-Dimethyl-2-oxobutyl)phosphonate; (3,3-Dimethyl-2-oxobutyl)phosphonic Acid Diethyl Ester; Diethyl Pivaloylphosphonate; Diethyl Pivaloylphosphonate; Diethyl (3,3-Dimethyl-2-oxobutyl)phosphonate; Diethyl (2-Oxo-3,3-dimethylbutyl)phosphonate; Pivaloylphosphonate Diethyl Ester; Horner-Wadsworth-Emmons Reagent for Pivalaldehyde
EINECS	212-389-4

Quality Control

Our Diethyl (3,3-Dimethyl-2-Oxobutyl)Phosphonate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.