Description

2,2,2-Trifluoro-1,1-Dimethyl-Ethylamine is a versatile fluorinated amine building block characterized by its high volatility and strong basicity in organic solvents. This compound is critical for introducing the trifluoroethylamine moiety, a key structural feature that can dramatically alter the physicochemical properties of target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates, active ingredients, and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated amine groups to enhance metabolic stability, bioavailability, or membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluorine atoms contribute to improved efficacy and environmental profile.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in asymmetric catalysis and organometallic chemistry.
• Material Science: Employed in the synthesis of fluorinated polymers, surfactants, and specialty materials with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution and condensation reactions to incorporate the 2,2,2-trifluoro-1,1-dimethylethyl group into complex organic frameworks.
• Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in both academic and industrial settings.

Basic Information

Product Name	2,2,2-Trifluoro-1,1-Dimethyl-Ethylamine
CAS No.	812-18-0
Molecular Formula	C4H8F3N
Molecular Weight	127.11 g/mol
Synonyms	1,1-Dimethyl-2,2,2-trifluoroethylamine; 2,2,2-Trifluoro-tert-butylamine; (Trifluoromethyl)dimethylmethylamine; 2-Amino-1,1,1-trifluoro-2-methylpropane; 2,2,2-Trifluoro-N,N-dimethyl-ethanamine; α,α,α-Trifluoro-tert-butylamine; TFBA; TFB amine
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1,1-Dimethyl-Ethylamine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency meet the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its high volatility and strong basicity, ensure containers are properly sealed and stored away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.