Description

3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoic Acid is a high-value, synthetically versatile boronic ester derivative, serving as a critical building block in modern organic synthesis. Its core value proposition lies in enabling precise carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and OLED materials industries, where it is used to construct complex molecular architectures with high efficiency and selectivity.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of biaryl and other carbon-carbon bonds under mild conditions, crucial for constructing complex organic molecules.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl motifs.
• OLED and Electronic Materials: Serves as a precursor for creating organic light-emitting diodes (OLEDs), semiconductors, and other advanced functional materials.
• Polymer Chemistry: Incorporated into polymer backbones to create specialty polymers with tailored properties for high-performance applications.
• Ligand and Catalyst Development: Utilized in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed in the synthesis of molecular probes and bifunctional degraders for target protein degradation research.
• Academic & Contract Research: A fundamental reagent in university and CRO (Contract Research Organization) laboratories for methodological development and discovery chemistry.

Basic Information

Product Name	3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoic Acid
CAS No.	797755-11-4
Molecular Formula	C15H21BO4
Molecular Weight	276.14 g/mol
Synonyms	3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]propanoic Acid; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenepropanoic Acid; 3-(4-(Pinacolboryl)phenyl)propionic Acid; 4-(3-Carboxyethyl)phenylboronic Acid Pinacol Ester; 3-(4-Boronic Acid Pinacol Ester Phenyl)Propionic Acid; 797755-11-4; Boric acid, B-[4-(2-carboxyethyl)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for research and development as well as scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0% (Area %)
Water Content (KF)	≤0.5% w/w
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.