Description

n-(3-Fluorophenyl)-N'-[4-(4,4,5,5-Tetramethyl-[1,3,2]-Dioxaborolan-2-Yl)Phenyl]Urea is a high-purity, advanced pharmaceutical intermediate featuring a boronic ester pinacol group, making it a critical building block for modern drug discovery. This compound is specifically designed for Suzuki-Miyaura cross-coupling reactions, enabling the efficient synthesis of complex biaryl structures. It is essential for research and development in medicinal chemistry, particularly for creating targeted therapies in oncology and CNS disorders.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for small molecule drugs.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds between aryl halides and the boronic ester moiety, a cornerstone reaction in medicinal chemistry.
• Kinase Inhibitor Development: Serves as a core scaffold in the research and production of tyrosine kinase inhibitors for cancer treatment.
• Proteolysis Targeting Chimera (PROTAC) Synthesis: Employed in constructing bifunctional molecules for targeted protein degradation.
• Material Science Research: Used in the development of organic electronic materials and advanced polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development.

Basic Information

Product Name	n-(3-Fluorophenyl)-N'-[4-(4,4,5,5-Tetramethyl-[1,3,2]-Dioxaborolan-2-Yl)Phenyl]Urea
CAS No.	796967-57-2
Molecular Formula	C19H22BFN2O3
Molecular Weight	356.20 g/mol
Synonyms	1-(3-Fluorophenyl)-3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]urea; 3-Fluoro-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbanilide; Urea, N-(3-fluorophenyl)-N'-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 796967-57-2; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl 3-fluorophenylcarbamate (precursor); BoroFluoro Urea Intermediate
EINECS	Contact for details

Quality Control

Every batch of our n-(3-Fluorophenyl)-N'-[4-(4,4,5,5-Tetramethyl-[1,3,2]-Dioxaborolan-2-Yl)Phenyl]Urea is manufactured under cGMP-like conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes full traceability and compliance with REACH regulations for global supply. Comprehensive Certificates of Analysis (COA) detailing purity, impurity profiles, and spectroscopic data are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and easily oxidized nature. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Single Maximum Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.