Description

1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-3-(3-(Trifluoromethyl)Phenyl)Urea is a high-value, functionalized chemical intermediate designed for advanced synthesis. This compound is strategically important for its dual functionality, combining a protected boronic ester group with a urea linkage, enabling precise molecular construction. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for creating novel active ingredients and complex organic frameworks.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, particularly in kinase inhibitor and targeted therapy research.
• Suzuki-Miyaura Cross-Coupling Reactions: The protected boronic ester moiety serves as a stable precursor for palladium-catalyzed cross-coupling to form biaryl structures.
• Agrochemical Research: Used in the development of new herbicides and fungicides with enhanced efficacy and selectivity.
• Material Science: Intermediate for creating functional polymers and organic electronic materials with specific electronic properties.
• Chemical Biology Probes: Utilized in the design of molecular probes for studying enzyme function and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for client R&D programs.

Basic Information

Item	Detail
Product Name	1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-3-(3-(Trifluoromethyl)Phenyl)Urea
CAS No.	796967-48-1
Molecular Formula	C20H22BF3N2O3
Molecular Weight	406.21 g/mol
Synonyms	N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]urea; 1-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-3-[3-(trifluoromethyl)phenyl]urea; Urea, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]-; B-[4-[[[[3-(Trifluoromethyl)phenyl]amino]carbonyl]amino]phenyl]boronic acid, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)-3-(3-(Trifluoromethyl)Phenyl)Urea is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.