Description

Oxirane, 2-(2,2-Difluoro-1-methylethenyl)-3-(4-methylphenyl)-, (2R,3R)-rel- (9Ci) is a high-purity, stereochemically defined oxirane derivative, also known as a fluorinated epoxide, which serves as a critical chiral building block in advanced organic synthesis. Its value lies in the precise introduction of fluorine atoms and a chiral oxirane ring, enabling the construction of complex molecules with tailored biological and physical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability and potency.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced, fluorinated pesticides and herbicides, where fluorine incorporation can improve lipophilicity, membrane permeability, and environmental stability.
• Material Science Research: Serves as a monomer or precursor for specialty polymers and advanced materials, leveraging the oxirane ring for polymerization and the fluorine for surface property modification.
• Asymmetric Catalysis Studies: Employed as a model substrate in academic and industrial research to develop and test new catalytic methods for stereoselective ring-opening reactions.
• Liquid Crystal & OLED Precursor: A potential building block for fluorinated organic electronic materials, where its structure can influence charge transport and self-assembly properties.

Basic Information

Product Name	Oxirane, 2-(2,2-Difluoro-1-methylethenyl)-3-(4-methylphenyl)-, (2R,3R)-rel- (9Ci)
CAS No.	791809-65-9
Molecular Formula	C12H12F2O
Molecular Weight	210.22 g/mol
Synonyms	rel-(2R,3R)-2-(2,2-Difluorovinyl)-3-(p-tolyl)oxirane; (2R,3R)-rel-2-(2,2-Difluoroethenyl)-3-(4-methylphenyl)oxirane; 2-(2,2-Difluorovinyl)-3-(4-methylphenyl)oxirane, (2R,3R)-rel-; Fluorinated p-Tolyloxirane; (2R*,3R*)-2-(2,2-Difluoroethenyl)-3-(4-methylphenyl)oxirane; Chiral Difluoro Epoxide Building Block; 791809-65-9 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Every batch of our high-value chiral intermediates is produced and tested under a strict quality management system. We employ advanced analytical techniques including chiral HPLC, GC, NMR, and MS to ensure excellent enantiomeric excess (ee) and chemical purity, meeting the stringent requirements of process chemistry and regulatory starting material guidelines. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to the reactive epoxide moiety, store separately from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for specified enantiomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.