Description

1H-Indene-1-Carboxaldehyde,5-Fluoro-2,3-Dihydro-,(1R)-(9Ci) is a high-purity, chiral fluorinated indene derivative, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in its unique stereochemistry and fluorine substitution, which are essential for modulating the biological activity, metabolic stability, and lipophilicity of target drug molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug discovery.
• Agrochemical Research: Used in the development of new-generation herbicides and pesticides, where the fluorine atom enhances bioactivity and environmental stability.
• Asymmetric Synthesis: Employed as a chiral aldehyde precursor in stereoselective reactions, such as aldol condensations and reductive aminations, to construct complex molecular architectures.
• Material Science Precursor: Acts as a monomer or functionalization agent in the research of specialty polymers and advanced organic materials with tailored electronic properties.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies to explore and optimize drug candidate profiles.

Basic Information

Product Name	1H-Indene-1-Carboxaldehyde,5-Fluoro-2,3-Dihydro-,(1R)-(9Ci)
CAS No.	789632-01-5
Molecular Formula	C10H7FO
Molecular Weight	162.16 g/mol
Synonyms	(1R)-5-Fluoro-2,3-dihydro-1H-indene-1-carboxaldehyde; (R)-5-Fluoroindan-1-carboxaldehyde; 5-Fluoro-2,3-dihydro-1H-indene-1-carbaldehyde, (1R)-; (R)-5-Fluoro-2,3-dihydro-1H-indene-1-carbaldehyde; (1R)-5-Fluoroindan-1-carbaldehyde; (R)-5-Fluoro-1-indanecarboxaldehyde; 789632-01-5; (R)-5-Fluoro-2,3-dihydroinden-1-carbaldehyde
EINECS	Contact for details

Quality Control

Every batch of 1H-Indene-1-Carboxaldehyde,5-Fluoro-2,3-Dihydro-,(1R)-(9Ci) is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity compliant with cGMP standards for advanced intermediates. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.