Description

(1S,2S,3R,5S)-Pinanediol-L-Phenylalanine-L-Leucine Boronate, Hcl Salt is a high-purity, chiral boronic acid derivative used as a critical intermediate in advanced pharmaceutical synthesis. This compound matters for its role in facilitating key chemical transformations, particularly in the development of protease inhibitors and other therapeutic agents. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel drug candidates and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of protease inhibitors and other active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a chiral auxiliary or reagent in stereoselective organic reactions.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Peptidomimetic Development: Used in the design and synthesis of peptide analogs with enhanced metabolic stability and bioavailability.
• Bioconjugation: Potential use in the development of targeted drug delivery systems and diagnostic agents.
• Chemical Biology Probes: Acts as a tool compound for studying enzyme mechanisms and biological pathways.

Basic Information

Product Name	(1S,2S,3R,5S)-Pinanediol-L-Phenylalanine-L-Leucine Boronate, Hcl Salt
CAS No.	789472-91-9
Molecular Formula	C26H41BN2O5 • HCl
Molecular Weight	507.90 g/mol (Free base: 472.43 g/mol)
Synonyms	L-Phenylalanine-L-leucine boronate pinanediol ester hydrochloride; (1S,2S,3R,5S)-Pinanediol (S)-2-((S)-2-amino-3-phenylpropanamido)-4-methylpentan-1-ylboronate hydrochloride; Boronic acid peptide derivative; Pinanediol-protected amino acid boronate; CAS 789472-91-9; Boronate ester intermediate; Chiral boronic acid peptide conjugate
EINECS	Contact for details

Quality Control

Our (1S,2S,3R,5S)-Pinanediol-L-Phenylalanine-L-Leucine Boronate, Hcl Salt is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing specifications such as assay, chiral purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.