Description

Cyclopropanecarboxylic Acid, 1-Amino-2-(1-Methylethyl)-, Methyl Ester, trans- CAS NO 787522-21-8 is a high-purity, chiral cyclopropane derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the unique structural rigidity and stereochemistry of the cyclopropane ring, which is leveraged to modulate the biological activity and physical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, antiviral agents, and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, where the cyclopropane moiety can enhance stability and efficacy.
• Chiral Auxiliary/Resolution Agent: Employed in asymmetric synthesis and chiral separations due to its defined stereochemistry at multiple centers.
• Chemical Biology Probe Development: Serves as a precursor for labeled compounds or molecular probes used in studying biological pathways and target engagement.
• Material Science Research: Investigated as a monomer or additive for creating polymers with specific thermal or mechanical properties derived from the strained ring system.
• Process Chemistry & Scale-up: Utilized in route development and optimization for the commercial production of fine chemicals and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 1-Amino-2-(1-Methylethyl)-, Methyl Ester, trans-
CAS No.	787522-21-8
Molecular Formula	C9H17NO2
Molecular Weight	171.24 g/mol
Synonyms	trans-1-Amino-2-isopropylcyclopropanecarboxylic acid methyl ester; Methyl trans-1-amino-2-isopropylcyclopropanecarboxylate; (1R,2S)- or (1S,2R)-1-Amino-2-(propan-2-yl)cyclopropane-1-carboxylic acid methyl ester; 2-Isopropyl-1-aminocyclopropanecarboxylic acid methyl ester, trans-; AICM ester; trans-2-Isopropyl-1-aminocyclopropanecarboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 1-Amino-2-(1-Methylethyl)-, Methyl Ester, trans- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (diastereomeric excess)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.