Description

1,2,4-Trioxolane,3,5-Bis(Chloromethyl)-3-Methyl-5-(2-Propenyl)-,(3R,5S)-Rel-(9Ci) is a specialized, high-purity synthetic intermediate of significant interest in advanced organic synthesis. This compound matters for its unique trioxolane (ozonide) core, which serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals. Industrial and pharmaceutical R&D laboratories require this precise stereoisomer for its role in creating complex molecular architectures with potential therapeutic applications.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antimalarial and antiparasitic drug candidates leveraging the 1,2,4-trioxolane pharmacophore.
• Organic Synthesis Building Block: Used in cycloaddition and functionalization reactions to introduce the ozonide moiety into complex molecules.
• Peroxide Chemistry Research: Serves as a model compound in studies of stable cyclic peroxide reactivity and decomposition pathways.
• Fine Chemical Production: Intermediate for manufacturing specialized agrochemicals and performance materials requiring specific oxidative properties.
• Academic & R&D: Critical reagent for medicinal chemistry programs and methodological development in synthetic organic chemistry laboratories.

Basic Information

Product Name	1,2,4-Trioxolane,3,5-Bis(Chloromethyl)-3-Methyl-5-(2-Propenyl)-,(3R,5S)-Rel-(9Ci)
CAS No.	783340-75-0
Molecular Formula	C9H14Cl2O3
Molecular Weight	241.11 g/mol
Synonyms	(3R,5S)-3,5-Bis(chloromethyl)-3-methyl-5-(prop-2-en-1-yl)-1,2,4-trioxolane; 3,5-Bis(chloromethyl)-3-methyl-5-(2-propenyl)-1,2,4-trioxolane, (3R,5S)-rel-; OZ277 derivative; Synthetic ozonide intermediate; 1,2,4-Trioxolane, 3,5-bis(chloromethyl)-3-methyl-5-(2-propenyl)-, (3R,5S)-rel-; Artemisinin derivative intermediate; Cyclic peroxide intermediate; (rel)-(3R,5S)-3,5-Bis(chloromethyl)-3-methyl-5-(prop-2-enyl)-1,2,4-trioxolane
EINECS	Contact for details

Quality Control

Our 1,2,4-Trioxolane,3,5-Bis(Chloromethyl)-3-Methyl-5-(2-Propenyl)-,(3R,5S)-Rel-(9Ci) is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, stereochemical identity, and impurity profiles. We adhere to cGMP principles where applicable to support pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its properties as a strong oxidizer and light-sensitive material, keep away from heat, sparks, open flames, and incompatible materials such as reducing agents and strong bases. Isolate from other stored chemicals.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.