Description

4-Nitro-L-Phenylalanine Ethyl Ester is a protected derivative of the non-natural amino acid 4-nitro-L-phenylalanine. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, particularly for the development of pharmaceuticals and bioactive peptides. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity, enantiomerically pure intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based drugs.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the nitro-phenylalanine moiety into peptide sequences for research and therapeutic applications.
• Proteomics & Biochemical Research: Serves as a precursor for fluorescent probes, enzyme inhibitors, and other tools used in studying protein function and interactions.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Material Science: Potential use in the synthesis of specialty polymers and advanced materials requiring specific aromatic amino acid derivatives.

Basic Information

Product Name	4-Nitro-L-Phenylalanine Ethyl Ester
CAS No.	780004-06-0
Molecular Formula	C11H14N2O4
Molecular Weight	238.24 g/mol
Synonyms	L-4-Nitrophenylalanine ethyl ester; Ethyl (2S)-2-amino-3-(4-nitrophenyl)propanoate; (S)-Ethyl 2-amino-3-(4-nitrophenyl)propanoate; 4-Nitro-L-phenylalanine ethyl ester; 4-Nitro-L-Phe-OEt; H-4-NO2-Phe-OEt; Fmoc-4-Nitro-L-phenylalanine ethyl ester (protected form); 4-Nitrophenylalanine ethyl ester, L-
EINECS	Contact for details

Quality Control

Our 4-Nitro-L-Phenylalanine Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination, to ensure it meets the stringent requirements for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.