Description

4-Nitro-5-(Trifluoromethyl)-2-[2-(Trimethylsilyl)-Ethynyl]Phenylamine is a high-value, multi-functional aromatic amine building block characterized by its nitro, trifluoromethyl, and silyl-protected ethynyl substituents. This compound is engineered to serve as a critical intermediate in advanced organic synthesis, offering unique reactivity for constructing complex molecular architectures. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, leveraging the trifluoromethyl group for enhanced biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for organic electronic materials, where the conjugated ethynyl system can be utilized in molecular wires, semiconductors, or nonlinear optical materials.
• Cross-Coupling Reactions: The silyl-protected alkyne functionality makes it a valuable substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions for carbon-carbon bond formation.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.
• Fluorine Chemistry: Acts as a versatile building block for introducing the trifluoromethyl group into more complex molecules, a sought-after moiety in drug design for its lipophilicity and stability.

Basic Information

Product Name	4-Nitro-5-(Trifluoromethyl)-2-[2-(Trimethylsilyl)-Ethynyl]Phenylamine
CAS No.	1186405-13-9
Molecular Formula	C14H15F3N2O2Si
Molecular Weight	328.37 g/mol
Synonyms	2-Amino-4-nitro-5-(trifluoromethyl)phenyl(trimethylsilyl)acetylene; 2-[(Trimethylsilyl)ethynyl]-4-nitro-5-(trifluoromethyl)aniline; 4-Nitro-5-(trifluoromethyl)-2-[(trimethylsilyl)ethynyl]benzenamine; 2-Ethynyl-4-nitro-5-(trifluoromethyl)aniline, trimethylsilyl ether; TMS-protected 2-ethynyl-4-nitro-5-(trifluoromethyl)aniline
EINECS	Contact for details

Quality Control

Our production of 4-Nitro-5-(Trifluoromethyl)-2-[2-(Trimethylsilyl)-Ethynyl]Phenylamine adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.