Description

(R)-Boroleu-(+)-Pinanediol-Hcl CAS NO 779357-85-6 is a high-purity, chiral boronic ester derivative used as a critical intermediate in advanced organic synthesis. This compound matters for its role in facilitating stereoselective transformations, particularly in the synthesis of complex pharmaceutical molecules and novel materials. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications requiring precise control over molecular chirality.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting neurological and metabolic disorders.
• Asymmetric Synthesis: Employed in Suzuki-Miyaura and other cross-coupling reactions to introduce chiral centers with high enantiomeric purity.
• Agrochemical Research: Used in the development of novel, enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor for creating chiral ligands, catalysts, and functionalized polymers with specific optical properties.
• Academic & Contract Research: A valuable reagent for methodological development in organic chemistry and for producing reference standards in analytical laboratories.

Basic Information

Product Name	(R)-Boroleu-(+)-Pinanediol-Hcl
CAS No.	779357-85-6
Molecular Formula	C₁₆H₂₈BClNO₂
Molecular Weight	311.66 g/mol
Synonyms	(R)-Leucine Boronic Acid Pinanediol Ester Hydrochloride; (R)-2-Amino-4-methylpentan-1-ol, 1-boronate, hydrochloride, (1S,2R,3S,5S)-2,6,6-trimethylbicyclo[3.1.1]heptan-3-yl ester; (R)-Boc-Leu-B(pin)-OH·HCl; (R)-N-Boc-4-methyl-2-((4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)methyl)pentanoic acid hydrochloride; Boroleucine pinacol ester hydrochloride, (R)-isomer; (R)-α-Aminoboronic acid derivative of leucine.
EINECS	Contact for details

Quality Control

Every batch of (R)-Boroleu-(+)-Pinanediol-Hcl is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment aligns with cGMP principles where applicable, and we provide comprehensive Certificates of Analysis (COA) for traceability and regulatory support. Specifications are designed to meet the stringent requirements of pharmaceutical development and advanced research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.