Description

Thiophene, 3,3-Difluorotetrahydro-, 1,1-Dioxide (9Ci) is a high-value, fluorinated heterocyclic sulfone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both fluorine atoms and a sulfone group, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the difluoro and sulfone motifs can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a specialized monomer or building block for advanced polymers and functional materials, such as sulfone-containing polymers for high-performance applications.
• Ligand and Catalyst Development: Employed in the design of novel chiral ligands and organocatalysts for asymmetric synthesis, leveraging the stereogenic center and electron-withdrawing groups.
• Fluorine Chemistry Research: An important substrate for studying fluorination reactions and the influence of gem-difluoro groups on molecular conformation and reactivity.

Basic Information

Product Name	Thiophene, 3,3-Difluorotetrahydro-, 1,1-Dioxide (9Ci)
CAS No.	779355-86-1
Molecular Formula	C4H4F2O2S
Molecular Weight	154.14 g/mol
Synonyms	3,3-Difluorotetrahydrothiophene 1,1-Dioxide; Tetrahydro-3,3-difluorothiophene 1,1-Dioxide; 3,3-Difluorotetrahydrothiophene Sulfone; 3,3-Difluorothiolane 1,1-Dioxide; 3,3-Difluorothiolane Sulfone; 3,3-Difluorothiolane-1,1-dione (incorrect but common); 3,3-Difluoro-1λ⁶-thiolane-1,1-dione (systematic); 779355-86-1
EINECS	Contact for details

Quality Control

Our Thiophene, 3,3-Difluorotetrahydro-, 1,1-Dioxide (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.